I've been working with a shared Waters 2695 with a 2996 DAD for the past year, and another user pumped 0.2M phosphate buffered mobile phase through the instrument (with their column) about 6 months ago. This change in mobile phase originally manifested as over-pressure issues, but copious flushing with warm water and isopropanol—and backflushing my column—eventually solved those issues & the instrument has run without fault for the past 4 months.

However, I am now getting a "Plunger Homing Fault (0)" error popping up twice during the instrument's self-initialization. Once before carousel initialization (which can be dismissed) & permanently afterwards. Unfortunately the initialization is required for any direct control of the instrument. This particular error message is not described in the 2695 Separations Module manual, [however the Waters support website describes this error appearing after using buffered mobile phases](https://support.waters.com/KB_Inst/Chromatography/WKB6

Having worked in an academic chemistry lab after the 2008 death at UCLA, I always wondered about the actual statistical relation described in this paper.

Personally, I think universities and colleges don't go far enough in educating workers on how to integrate safer approaches into all the highest risk processes done in their research labs. This paper seems to show that what has been implemented so far is not a significant impediment to research output either.