Currently trying Pop_OS in a VM.
Long way to go but the fact it presents the accessibility options the first time you log in post install shows some thought has been put into it. Magnifier is present, and unlike Mint there's an invert color option. Haven't explored enough to see if any of this can be globally bound to keyboard shortcuts. Orca still craps the bed as soon as it's started but that might be due to the VM not playing nice with audio. My use case is reading text under the mouse. It has to be responsive and it has to read more than just a line. Paragraphs are usually the ideal.
I tried asking a question on Blender Guru’s (the donut guy) discord and it just got swept away like a barrel over Niagara Falls, never to be seen again.